Table 1.

Effect of resveratrol and its derivatives on human HL-60 and THP-1 cell viability (IC50; μM)

Tested compounds	IC50 (μM)
	HL-60		THP-1
	24 h	48 h	24 h	48 h
3,5,4′-trihydroxy-trans-stilbene (Resveratrol)	59.98 ± 1.54	46.84 ± 1.92	130.05 ± 1.37#	79.02 ± 1.63##
3,4,4′-trimethoxy-trans-stilbene (3,4,4′-tri-MS)	51.36 ± 2.09*	41.32 ± 1.70	97.25 ± 3.11*,#	62.81 ± 1.83*,##
3,4,2′-trimethoxy-trans-stilbene(3,4,2′-tri-MS)	58.27 ± 1.47	46.34 ± 1.89	121.41 ± 2.08#	75.20 ± 2.64##
3,4,2′,4′-tetramethoxy-trans-stilbene (3,4,2′,4′-tetra-MS)	55.35 ± 2.23	43.01 ± 2.68	117.35 ± 3.68*,#	70.48 ± 2.45##
3,4,2′,6′-tetramethoxy-trans-stilbene (3,4,2′,6′-tetra-MS)	61.32 ± 3.80	40.00 ± 3.04	127.60 ± 3.24#	77.26 ± 3.17##
3,4,2′,4′,6′-pentamethoxy-trans-stilbene (3,4,2′4′,6′-penta-MS)	56.85 ± 1.17	44.52 ± 2.40	118.52 ± 3.05#	77.71 ± 1.91##

The cells were treated for 24 and 48 h with different concentrations of methoxy stilbenes or resveratrol and IC50 values were obtained by plotting log (% inhibition/100 − % inhibition) vs log (concentration), where % inhibition = (100 − viability) based on means ± SEM from three independent experiments

*p < 0.05 compared to resveratrol treated cells; ^#p < 0.05 compared to HL-60 cells treated for 24 h; ^##p < 0.05 compared to HL-60 cells treated for 48 h