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. 2020 Sep 16;11:578878. doi: 10.3389/fmicb.2020.578878

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Copyright © 2020 Heinilä, Fewer, Jokela, Wahlsten, Jortikka and Sivonen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The scytocyclamide (lxa) biosynthetic gene cluster and putative biosynthetic scheme. (A) Organization of predicted scytocyclamide biosynthetic genes. (B) Proposed biosynthetic pathway of scytocyclamides. NRPS, Non-ribosomal peptide synthetase, PKS, Polyketide synthase, FAAL, Fatty acyl AMP Ligase, ACP, acyl carrier protein, KS, ketosynthase, AT, acyltransferase, AMT, aminotransferase, C, condensation domain, A, adenylation domain, T, thiolation domain, M, methylation domain, TE, thioesterase domain.