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. 2020 Sep 16;11:578878. doi: 10.3389/fmicb.2020.578878

TABLE 1.

Amino acid sequence of laxaphycin variants.

Amino acid residue Ref.
11-residue laxaphycins 1 2 3 4 5 6 7 8 9 10 11
Laxaphycin A Aoa Hse Dhb OHPro HSe Phe Leu Ile Ile Leu Gly 1
Laxaphycin A2 Aoa Hse Dhb OHPro HSe Phe Leu Val Ile Leu Gly 10
Laxaphycin E Ada Hse Dhb OHPro HSe Phe Leu Ile Ile Leu Gly 1
Hormothamnin A Aoa Hse Dhb OHPro HSe Phe Leu Ile Ile Leu Gly 2
Lobocyclamide A Aoa Ser Dhb OHPro HSe Tyr Leu Ile Ile Leu Gly 3
Trichormamide A Ada Ser Ser Pro Ser Tyr Leu Ile Ile Pro Gly 7
Trichormamide D Ada Gln Dhb Pro Ser Tyr Leu Val Phe Leu Gly 8
Scytocyclamide A Aoa Gln Dhb OHPro HSe Phe Leu Ile Ile Leu Gly 4
[L-Val8]laxaphycin A Aoa Hse Dhb OHPro HSe Phe Leu Val Ile Leu Gly 11
[D-Val9]laxaphycin A Aoa Hse Dhb OHPro HSe Phe Leu Ile Val Leu Gly 11
Acyclolaxaphycin A H-Aoa Hse Dhb OHPro HSe Phe Leu Ile Ile Leu Gly-OH 11
[des-Gly11] acyclolaxaphycin A H-Aoa Hse Dhb OHPro HSe Phe Leu Ile Ile Leu-OH 11
[des-(Leu10-Gly11)] acyclolaxaphycin A H-Aoa Hse Dhb OHPro HSe Phe Leu Ile Ile-OH 11
12-residue laxaphycins 1 2 3 4 5 6 7 8 9 10 11 12 Ref.
Laxaphycin B Ada Val OHLeu Ala OHLeu Gln NMe-Ile OHAsn Thr Pro Leu Thr 1
Laxaphycin B2 Ada Val OHLeu Ala Leu Gln NMe-Ile OHAsn Thr Pro Leu Thr 5
Laxaphycin B3 Ada Val OHLeu Ala OHLeu Gln NMe-Ile OHAsn Thr OHPro Leu Thr 5
Laxaphycin B4 Ada Val OHLeu Hse OHLeu Gln NMe-Ile OHAsn Thr OHPro Leu Thr 10
Laxaphycin B5 Ada Ile OHLeu Val OHLeu Gln NMe-Ile Asn Thr Pro Tyr Thr 12
Laxaphycin B6 Ada Ile OHLeu Val Leu Gln NMe-Ile Asn Thr Pro Tyr Thr 12
Laxaphycin D Aoa Val OHLeu Ala OHLeu Gln NMe-Ile OHAsn Thr Pro Leu Thr 1
Lobocyclamide B Ada Val OHLeu Ala OHLeu Gln NMe-Ile OHThr Thr OHPro Leu Thr 3
Lobocyclamide C Aoa Val OHLeu Ala OHLeu Gln NMe-Ile OHThr Thr OHPro Leu Thr 3
Lyngbyacyclamide A Ada Val OHLeu Hse Leu Gln NMe-Ile OHAsn Thr Pro Phe Thr 6
Lyngbyacyclamide B Ada Val OHLeu Hse Leu Gln NMe-Ile OHAsn Thr OHPro Phe Thr 6
Trichormamide B Ada Ile OHLeu Hse OHLeu Gln NMe-Ile Ser Thr Pro Tyr Thr 7
Trichormamide C Ada Val OHLeu Ala OHLeu Gln NMe-Ile Asn Thr Pro Leu Thr 8
Acyclolaxaphycin B Ada Val OHLeu-OH H-Ala OHLeu Gln NMe-Ile OHAsn Thr Pro Leu Thr 9
Acyclolaxaphycin B3 Ada Val OHLeu-OH H-Ala OHLeu Gln NMe-Ile OHAsn Thr OHPro Leu Thr 9
Scytocyclamide B Aoa Val OHLeu Ala OHLeu Gln NMe-Ile OHAsn Thr Pro Leu Thr 4
Scytocyclamide C Aoa Val OHLeu Ala Leu Gln NMe-Ile OHAsn Thr Pro Leu Thr 4

1 Frankmölle et al. (1992b), 2 Gerwick et al. (1992), 3 MacMillan et al. (2002), 4 Grewe (2005), 5 Bonnard et al. (2007), 6 Maru et al. (2010), 7 Luo et al. (2014), 8 Luo et al. (2015), 9 Bornancin et al. (2015), 10 Cai et al. (2018), 11 Bornancin et al. (2019), 12 Sullivan et al. (2020). Aoa – β-aminooctanoic acid, Ada - β-aminodecanoic acid, Hse - Homoserine, Dhb - Dehydrobutyrine, NMe-Ile – N-Methyl Isoleucine, OHPro – 4-hydroxyproline, OHAsn – 3-hydroxyasparagine, OHLeu – 3-hydroxyleucine, OHThr – 4-hydroxythreonine.