Fig. 3.
Modulatory effects of WJ-MSC therapy on expression of regenerative and fibrotic markers in TAA-injured mouse livers. A NOD-SCID mice received intraperitoneal TAA injection twice weekly for 6 weeks and received MSC infusion (3 × 105 cells per mouse) or PBS as vehicle control. After 3, 7, and 14 days of WJ-MSC therapy, liver tissue and plasma proteins were collected for western blotting detection. Relative expression levels of target proteins were subsequently measured by densitometry, including B HGF, C PCNA, D Ets-1 p42, E total Smad2, F RhoA, G ERK1/2, and H plasma fibronectin (pFN). Data are mean ± SEM induction folds over control. *p < 0.05 compared with normal control (NC) or between indicated groups. NS, not significant