Fig. 5.

Circ_0068655 exerted its function via modulation of the circ_0068655/miR-498/PAWR axis. HCMs were co-transfected with shRNA against circ_0068655, miR-498 inhibitor, empty vector, or negative control inhibitor, followed by hypoxia incubation for 12 h. The A RNA and B protein expression of PAWR, C cell viability, D caspase-3 activity, E DNA fragment, F relative migration, and G invasion were determined by qRT-PCR, western blotting, MTT assay, Caspase-3 activity assay, cell death ELISA (POD) assay, and trans-well assay, respectively. The data are expressed as the mean ± SD, **p < 0.01