Fig. 1.

Strategy for the definition of the volume-of-interest for myocardial [¹¹C]mHED uptake. a Transversal planes of a cropped volume including the heart, from posterior (top left) to anterior (bottom right). SUV_1–61 min according to colour scale. b Voxel-wise slopes SUV/time between 11 and 48 min p.i. Slopes according to colour scale. Voxels with slopes ≥ − 0.012 SUV/min were excluded from the volume-of-interest, assuming spill-over from liver (liver radioactivity was increasing over time). c From the remaining voxels, the volume with highest SUV between 3 and 11 min p.i., corresponding to 0.5% of the individual body weight (i.e. body weight (g) × 0.005 cm³/g). Scan with 9.2 MBq [¹¹C]mHED (1.5 nmol/kg, including metaraminol mass), body weight 27.6 g