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. 2020 Sep 29;10:114. doi: 10.1186/s13550-020-00700-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Compartment models evaluated in this study. a One-tissue compartment model (TCM1). b Model with two parallel tissue compartments (TCM2p) both directly accessible from the input compartment. c Two-tissue compartment model with the two-tissue compartments in series (TCM2s), as applied for neuroreceptor PET. K₁ or k₃ would represent NET uptake. In the first case, k₃ would represent uptake into storage vesicles by vMAT2. In the latter case, K₁ would represent extravasation into interstitium. d Similar as c but with the second-tissue compartment releasing to the input compartment (k₄) rather than to the first tissue compartment. In this model, K₁ would represent NET uptake, k₃ uptake into storage vesicles by vMAT2, and k₄ release from storage vesicles into interstitial space (TCM2v, v for release from vesicles). C_a, [¹¹C]mHED activity concentration in arterial plasma (input function)