Fig. 3.

Standard PET images of myocardium after i.v. injection of [¹¹C]mHED or [¹⁸F]LMI1195 in FVB/N mice. a Representative short-axis (left column), horizontal long-axis (middle column), and vertical long-axis (right column) PET images at various extents of NET saturation with metaraminol (mHED with indication of total mass of [¹¹C]mHED and metaraminol) or desipramine (20 mg/kg desipramine HCl as indicated) and [¹⁸F]LMI1195 under baseline conditions or with desipramine. SUV was averaged from 1 to 31 min p.i. b TACs after injection of [¹¹C]mHED alone (9.2–16.6 nmol/kg, including metaraminol mass; n = 3) and [¹¹C]mHED (9.6–10.5 nmol/kg) + 20 mg/kg desipramine HCl (n = 3). c TACs after injection of [¹⁸F]LMI1195 alone (mass range, see Table 1; n = 6) and [¹⁸F]LMI1195 (mass range, see Table 1) + 20 mg/kg desipramine HCl (n = 6). Mean values with SD