Fig. 4.

Dose dependency of [¹¹C]mHED uptake in the mouse myocardium. a TACs (SUV) of myocardium at the indicated dose of combined [¹¹C]mHED and metaraminol. Desipramine, 66′000 nmol/kg, corresponds to 20 mg/kg desipramine HCl. Broken vertical lines indicate 1 and 31 min, respectively, the time window for SUV_1–31 min averaging. TACs with shorter time intervals are from the scans for kinetic modelling. b SUV_1–31 min was plotted against the dose on logarithmic scale (base 10). Solid line, fit according to Eq. 3 with fit D₅₀ = 88.3 nmol/kg. Broken lines, 95% confidence intervals. Broken vertical line indicates 1/10 D₅₀