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. 2020 Sep 29;10:114. doi: 10.1186/s13550-020-00700-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Generation of the input function. a Radioactivity fraction of parent tracer in plasma over time. b Ratio of activity concentration between plasma and whole blood over time. Lines are fit functions according to Eqs. 1 and 2, respectively, and as shown in the graphs. c Generated normalized (SUV) input functions of the 3 scans with blood coincidence measurements. d as c, emphasizing the first 5 min. Black, red, green, input functions; grey (lowest peak), whole blood SUV corresponding to the black input function (second lowest peak)