Fig. 3.

A–D In vitro growth factor release profile of VEGF and BMP-2. A Accumulative release profiles and C released dosage profiles from MCs containing VEGF with small size MC and B accumulative release profiles and D released dosage profiles from MCs containing BMP-2 with big size MC. Release profiles indicate a rapid burst release (within few hours) of growth factor from MCs. Both single and dual growth factor loaded MCs showed a sustained release profile that continued up to day 21. This indicates the possibility of regulating the amount of release of two growth factors in one type of MCs. SV: small size microcarrier with VEGF; SVBB: mixed microcarrier with BMP-2 and VEGF; BB: big size microcarrier with BMP-2