Fig. 9.

Light microscope images of the biocompatibility and osteoinductive potential of dual growth factor loaded MCs subcutaneously implanted in rats. Histological sections showing the residual scaffold materials which remained within fibrous capsule without degradation. rMSCs extended into the MCs (arrow head). In group SVBB, some ectopic bone formation (arrow) was observed in the space between MCs. H&E stain, magnification × 200, scale bar = 100 μm. S: small size microcarrier; B: big size microcarrier; SB: small and big size microcarrier; SV: small size microcarrier with VEGF; BB: big size microcarrier with BMP-2; SVBB: mixed microcarrier with BMP-2 and VEGF