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. 2020 Jul 8;16(3):347–366. doi: 10.1007/s11302-020-09711-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 10 — Combined pyrimidine metabolic rate–limiting enzymes have significant prognostic effects of in lung cancer. a Unsupervised clustering heatmap showed the division of two clusters of lung cancer patients by the expression levels of pyrimidine metabolic rate–limiting enzymes in GSE30219 dataset. Each line represented one patient. b The Kaplan-Meier plotter demonstrated the different clinical outcomes of those two clusters of lung cancer patients in GSE30219 dataset. The log-rank test was used to determine the overall survival P value. c Unsupervised clustering heatmap showed the division of two clusters of lung cancer patients by the expression levels of pyrimidine metabolic rate–limiting enzymes in TCGA LUAD dataset. d The Kaplan-Meier plotter demonstrated the different clinical outcomes of those two clusters of lung cancer patients in TCGA LUAD dataset. The log-rank test was used to determine the overall survival P value