Fig. 4.

Pyrimidine metabolic rate–limiting enzymes are upregulated in metastatic lung cancer cells and associated with lung cancer recurrence. a Heatmaps demonstrated the expression levels of pyrimidine metabolic rate–limiting enzymes in parental PC9 cells and PC9 BrM cells. b The Kaplan-Meier plotters demonstrated the associations between pyrimidine metabolic rate–limiting enzymes and lung cancer recurrence using the MSKCC dataset. The log-rank test was used to determine the overall survival P value. c The Kaplan-Meier plotters demonstrated the associations between purinergic receptors P2RX1, P2RX2, P2RY13, and P2RY14 and lung cancer recurrence using the MSKCC dataset