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. 2020 Jul 8;16(3):347–366. doi: 10.1007/s11302-020-09711-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Expression levels of pyrimidine metabolic rate limiting enzymes are associated with the tumor overall survival in lung cancer: analysis from GEO datasets. a The Kaplan-Meier plotters demonstrated the prognostic effects of the expression levels of pyrimidine metabolic rate–limiting enzymes TK1, UCK2, CAD, RRM1, RRM2, DTYMK, TYMS, TK2, and NR5C2 in lung cancer using the integrated GEO datasets. The patients were divided into two groups by the auto select best cutoff based on the expression levels of the pyrimidine metabolic rate–limiting enzymes. The log-rank test was used to determine the overall survival P value. b The Kaplan-Meier plotters demonstrated the prognostic effects of the expression levels of purinergic receptors P2RX1, P2RX2, P2RX7, P2RY12, P2RY13, and P2RY14 in lung cancer