Fig. 7.

Increased expression levels of the pyrimidine metabolic rate–limiting enzymes in lung cancer cells are induced by DNA hypomethylation. a Box plots demonstrated the DNA methylation intensity (β value) of pyrimidine metabolic rate limiting enzymes CAD, RRM2, and TK1 in normal lung tissues and lung adenocarcinoma tissues in GSE32867 dataset. b Box plots demonstrated the DNA methylation intensity of CAD, RRM2, and TK1 genes in normal lung tissues and lung adenocarcinoma tissues in GSE62948 dataset. c Heatmaps demonstrated the methylation level (β value) of the pyrimidine metabolic rate–limiting enzymes in normal and tumor tissues in LUAD. Hypermethylated (red), hypomethylated (green) and unchanged (black) genes were delineated