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. 2020 Sep 16;8:860. doi: 10.3389/fcell.2020.00860

FIGURE 1.

FIGURE 1

Stage-specific roles of Wnt signaling components in adult hippocampal neurogenesis. Schematic representation of the adult mouse hippocampus, and the stages of neurogenesis in the dentate gyrus. Type 1 NSCs proliferate asymmetrically to give rise to type 2 cells (types 2a and 2b), that differentiate into type 3 cells or neuroblast that develop into immature neurons, and ultimately into mature granule cells. The bottom panel indicates the temporal windows in which Wnt ligands, FZD receptors and co-receptors, Wnt signaling cascades and Wnt target genes have been involved (see text for details). DG, dentate gyrus; ML, molecular layer; GCL, granule cell layer; SGZ, subgranular zone.