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. 2020 Sep 16;10:487. doi: 10.3389/fcimb.2020.00487

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Copyright © 2020 Cao, Aguiar, Tremblay, Abbas, Tiessen, Revill, Makhdami, Ayoub, Cox, Ask, Doxey and Hirota.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Reduced expression of ABCF1 under VACV-70 stimulated conditions attenuates CXCL10 secretion. (A) Immunoblot confirming siRNA-mediated knockdown of ABCF1 protein expression in HBEC-6KT cells under experimental conditions of VACV-70 challenge. (B) Quantification of ABCF1 protein expression following siRNA treatment. (C) VACV-70 (3.16 μg/ml)-induced CXCL10 protein production for HBEC-6KT cells with ABCF1 siRNA treatment. Black bars: siCtrl treated. Gray bars: ABCF1 siRNA treated. (D) LDH quantification as a measure of cell viability following VACV-70 and siRNA treatment. (E) Phase-contrast microscopy (4X magnification) of HBEC-6KT following VACV-70 and siRNA treatment. All studies n = 3. ^*p < 0.05 and ^**p < 0.01.