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. 2020 Sep 16;10:530190. doi: 10.3389/fcimb.2020.530190

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Copyright © 2020 Chen, Li, Nie, Zhao, Yu, Li and Peng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Circadian rhythm disruption-driven coagulation prevents extravasation of S. oralis. (A) Routine coagulation array (4 mice/group) for whole blood in LD12:12 vs. jet-lag mice at ZT12. (B,C) Bodyweight and liver weight of mice in LD12:12 vs. jet-lag at ZT12. (D) Tail bleeding time of mice. (E) DNA extraction of EGFP-labeled S. oralis. Specific primers for GFP. (F,G) Imaging of mice in LD12:12 vs. jet-lag mice at ZT2 in vivo (4 mice/group). *P < 0.05; **P < 0.01; ***P < 0.005; ****P < 0.001.