Figure 4.

Transcriptomes in SF126 Cells Treated with Palmitoylation Inhibitors

(A–C) Heatmaps showing differentially expressed genes in SF126 cells treated with 2BP (A; 50 μM), Cer (B; 25 μM), or Tun (C; 2.5 μM) for 48 h. Euclidean distance was considered for row and column clustering. The color bars show the normalized effect of compounds on the gene expression levels (green indicates downregulated and red indicates upregulated) compared to cells treated with DMSO. Classification based on the biological process term on Gene Ontology analysis of upregulated mRNAs. (D) Venn diagrams showing the overlap of differentially expressed genes in the three treatment groups. Overlapping genes were generally classified on the basis of the biological process.