Table 3.
Methylation residues of AR.
| Residue | Location | Androgen | Regulator | Function | References |
|---|---|---|---|---|---|
| K349 | NTD | – | lncRNA/DOT1L | Promote transcriptional activity | 81 |
| K630/632 | Hinge | – | Set9 | Promote transcriptional activity | 90 |
| R761 | LBD | – | PRMT5 | Promote transcriptional activity | 91,92 |
NTD, N-terminal domain; LBD, ligand-binding domain; DOT1L, DOT1 like histone lysine methyltransferase; Set9, SET domain containing lysine methyltransferase 9; PRMT5, protein arginine methyltransferase 5; AR, androgen receptor. “–” means not clear.