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. 2020 Sep 16;14:571095. doi: 10.3389/fnins.2020.571095

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Copyright © 2020 Middlebrooks and Waters.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Interaural time difference (ITD) thresholds are elevated in humans affected with a dominant negative mutation in potassium channel Kv3.3. Participants were assigned to 3 groups on the basis of the molecular testing of the Kv3.3 gene: (1) age-matched non-familial controls; (2) unaffected familial controls; and (3) the affected group. The affected individuals are ranked left to right according to their SARA scores, shown at the top of the figure; SARA is an assessment of ataxia described in the text. Each vertical column of symbols represents 6 threshold measurements (X’s) and a median (horizontal bar) for one participant. Median ITDs in the two control groups were not significantly different from each other and were comparable to published reports of ITDs of untrained listeners. The median ITDs in the affected group were significantly greater than those in the control groups. (From Middlebrooks et al., 2013).