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. 2020 Sep 16;11:575953. doi: 10.3389/fneur.2020.575953

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Copyright © 2020 Bryant, Hu, Carlyle, Arnold, Frosch, Das, Hyman and Bennett.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NOS3 antemortem plasma expression is significantly associated with postmortem NOS3 gene expression in PFC capillaries of both B1 and B3 subjects. (A) Univariate regression of NOS3 plasma NPX (from final plasma sample per subject) vs. postmortem microvessel gene log2 fold change demonstrated a significant association between NPX and log2 fold change (β1 =1.022, p = 0.0024, BH-FDR = 0.0511). The shaded region indicates the 95% confidence interval of the regression slope. (B) After adjusting for years until death in multiple regression, there is still a significant association between NOS3 plasma NPX and postmortem capillary gene log2 fold change (β1 = 1.070, p = 0.0031, BH-FDR = 0.0660). For visualization, the adjusted log2 fold change values were calculated as the NPX β1 coefficient plus the partial residual associated between plasma NPX and years until death.