Table 1.
Top 10 overlapping gene ontology (GO) terms between Astragaloside IV targets and SARS-CoV-2 differentially expressed genes (DEGs).
| Category term | Description | Count | P value |
|---|---|---|---|
| GO:0002526 | cytokine-mediated signaling pathway | 53 | 2.22498E-10 |
| GO:0032755 | regulation of cytokine production | 41 | 2.05545E-06 |
| GO:0010874 | second-messenger-mediated signaling | 26 | 4.79803E-05 |
| GO:0002438 | positive regulation of cytokine production | 27 | 8.37368E-05 |
| GO:0002526 | cytokine secretion | 17 | 0.000161558 |
| GO:0032755 | regulation of cytokine secretion | 15 | 0.000335339 |
| GO:0002438 | negative regulation of protein secretion | 11 | 0.000653223 |
| GO:0002438 | negative regulation of peptide secretion | 11 | 0.00095377 |
| GO:0001730 | cellular calcium ion homeostasis | 24 | 0.001033831 |
| GO:0002438 | negative regulation of immune system process | 24 | 0.001200594 |