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. 2020 Sep 17;8:808. doi: 10.3389/fchem.2020.00808

Figure 1.

Figure 1

(LHS) One factor at a time (OFAT) for three variables [A: ChCl-Gly (mass% in water), B: SWNTs' concentration (mg/L), and C: Sonication energy (J/mL)] at five levels require 53 (=125) experiments without replicates. (RHS) Response surface methodology (RSM) reduces the number of experiments to 18 only. The circular points (at center, corners, and parallel to the face of the cube) represent the experimental runs. Central composite rotatable design (CCRD) of RSM, representing experimental points in the design space for three variables, is capable of navigating through the design space which is not possible with OFAT.