Table 3.
Mean V1 thickness (mean ± SD), V1 [11C]-PiB SUVR (mean ± SD), V1 [11C]-PK11195 BPND (mean ± SD), and retinal layers thicknesses (mean ± SD) per group. V1 [11C]-PiB uptake showed stark differences in Aβ load.
| Variable | AD group (N = 20) | HC group (N = 17) | p value |
|---|---|---|---|
| V1 (mm) | 1.974 (0.114) | 1.957 (0.133) | 0.719 |
| V1 [11C]-PiB SUVR | 1.4350 (0.290) | 1.033 (0.156) | <0.0001∗ |
| V1 [11C]- PK11195 BPND | 0.196 (0.060) | 0.205 (0.058) | 0.603 |
| GCL (μm) | 41.19 (3.59) | 42.067 (3.99) | 0.488 |
| IPL (μm) | 36.70 (3.16) | 36.15 (2.80) | 0.579 |
| INL (μm) | 36.82 (1.99) | 36.50 (2.10) | 0.646 |
| OPL (μm) | 30.42 (3.97) | 28.41 (2.17) | 0.104 |
V1: primary visual cortex; [11C]-PiB SUVR: Aβ PET radiotracer; [11C]-PK11195 BPND: neuroinflammation PET radiotracer binding potential; GCL: ganglion cell layer; IPL: inner plexiform layer; INL: inner nuclear layer; OPL: outer plexiform layer; ∗Bonferroni corrected for multiple comparisons.