Table 2. Plasma Concentrations of Steroids in Reference Patients With Hypertension, Patients With Primary Hypertension, and Patients with Bilateral Primary Aldosteronism or Unilateral Primary Aldosteronism Without and With KCNJ5 Sequence Variants.
| Steroid | Plasma concentration, least square geometric mean (95% CI), nmol/La | ||||
|---|---|---|---|---|---|
| Hypertension | Primary aldosteronism | ||||
| Reference | Primary | Bilateral | Unilateral with wild-type KCNJ5 | Unilateral with KCNJ5 variant | |
| Aldosterone | 0.091 (0.077-0.106) | 0.143 (0.119-0.169) | 0.260 (0.222-0.302) | 0.384 (0.312-0.463) | 0.436 (0.341-0.543) |
| 18-Oxocortisol | 0.026 (0.022-0.031) | 0.043 (0.035-0.052) | 0.056 (0.047-0.066) | 0.093 (0.074-0.114) | 0.578 (0.440-0.735) |
| 18-Hydroxycortisol | 1.62 (1.41-1.84) | 1.74 (1.50-1.99) | 1.75 (1.54-1.97) | 2.11 (1.79-2.46) | 6.960 (5.71-8.34) |
| Corticosterone | 4.28 (3.60-5.01) | 5.50 (4.57-6.53) | 7.21 (6.13-8.39) | 6.36 (5.15-7.70) | 7.11 (5.52-8.90) |
| 11-Deoxycorticosterone | 0.063 (0.052-0.075) | 0.112 (0.091-0.135) | 0.162 (0.136-0.191) | 0.277 (0.220-0.342) | 0.311 (0.235-0.397) |
| 11-Deoxycortisol | 1.332 (1.074-1.618) | 1.610 (1.275-1.985) | 2.935 (2.397-3.529) | 4.500 (3.455-5.686) | 2.917 (2.124-3.838) |
| 21-Deoxycortisol | 0.039 (0.030-0.050) | 0.044 (0.032-0.057) | 0.078 (0.060-0.099) | 0.083 (0.059-0.111) | 0.085 (0.056-0.120) |
| Cortisol | 237 (213-262) | 332 (296-370) | 327 (296-360) | 248 (218-280) | 274 (235-317) |
| Cortisone | 47.2 (43.2-51.4) | 53.2 (48.3-58.4) | 48.4 (44.5-52.5) | 35.5 (31.8-39.4) | 43.4 (38.2-49.1) |
| Androstenedione | 2.47 (2.25-2.70) | 2.69 (2.43-2.96) | 3.48 (3.19-3.79) | 2.87 (2.56-3.19) | 3.16 (2.76-3.58) |
| Dehydroepiandrosterone | 8.70 (7.66-9.81) | 7.91 (6.89-8.99) | 7.90 (7.01-8.85) | 6.19 (5.30-7.15) | 7.97 (6.63-9.45) |
| Dehydroepiandrosterone-sulfate | 3401 (3061-3758) | 2805 (2504-3125) | 2718 (2461-2987) | 2234 (1965-2520) | 2506 (2151-2888) |
| 17-Hydroxyprogesterone | 1.10 (0.96-1.24) | 1.39 (1.20-1.59) | 2.07 (1.83-2.33) | 1.95 (1.65-2.27) | 2.05 (1.68-2.45) |
| Progesterone | 0.336 (0.269-0.411) | 0.277 (0.217-0.344) | 0.595 (0.483-0.720) | 0.577 (0.438-0.735) | 0.431 (0.310-0.572) |
| Pregnenolone | 1.95 (1.61-2.32) | 2.12 (1.73-2.56) | 1.51 (1.26-1.78) | 2.09 (1.66-2.58) | 2.30 (1.74-2.94) |
a
Geometric means and 95% CIs were derived from the exponents of logarithmically transformed data. For whole model differences, see eTable 4 in the Supplement.