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. 2020 Sep 29;10:16007. doi: 10.1038/s41598-020-72563-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Histopathological examination in SARS-CoV-2 infected tree shrews. On 4, 7 and 14/16 dpi, tree shrews were euthanized and dissected. Tissues were collected from each animal for H&E staining and histopathological analysis. The histological sites with typical and representative lesions were zoomed in, which was described in text. (a) Histological lesions in the pulmonary tissues. The representative images were shown here from young, adult and old tree shrews dissected at the different stages of SARS-CoV-2 infection. (b) Histopathological changes in the other twelve tissues. Each image here represents one tissue of an animal, including weasand, Hilar, heart, liver, small intestine, pancreas, cecum, rectum, spleen, kidney, uterus, brain. Histopathological score of tissues in all tree shrews was summarized in Table 3.