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. 2020 Sep 29;11(9):813. doi: 10.1038/s41419-020-03018-3

Fig. 7. TRIM29 suppresses pre-miR873 cleaving to generate mature miRNAs via upregulation of CYTOR.

Fig. 7

a The abridged general view of potential binding sites between premiR-873 and CYTOR was showed according to online tool LncTar. b biotin-labeled premiR-873 was coincubated with CYTOR fragment to confirm their interaction by RNA EMSA. ce The expression of premiR-873 (c), miR-873-5p (d), and miR-873-3p (e) were analyzed using qRT-PCR in TPC1 cells with or without TRIM29 overexpression by CYTOR knockdown. fh The expression of premiR-873 (f), miR-873-5p (g), and miR-873-3p (h) were analyzed using qRT-PCR in IHH4 cells with or without TRIM29 knockdown by CYTOR overexpression. i, j Scatter plot showing the co-expression between CYTOR and hsa-miR-873-5P (i), hsa-miR-873-3P (j) in papillary cancer tissues according to online database (starbase.sysu.edu.cn). The data are presented as the mean (SD) of three repeated experiments. *P < 0.05, n.s. not significant.