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. 2020 Sep 29;10:16024. doi: 10.1038/s41598-020-72681-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Ghr reduces serum biomarkers of liver injury and inflammation in Mdr2KO mice. Liver transaminases ALT (A) and AST (B) were assessed in serum from Mdr2KO and FVBN mice when treated with vehicle, DG or Ghr. ALT and AST were quantified using an IDEXX analyzer system, as described under Methods. The proinflammatory cytokine CCL2 and the pro-fibrogenic growth factor TGFβ1 were assayed using ELISA kits. Number of animals of each treatment group, 4, and number of sample replicates for IDEXX and ELISA, 3. p < 0.05. *, Ghr or DG vs vehicle. # Mdr2KO vs FVBN mice.