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Circulating RAS analytes were measured in 24-month-old male F344/BN rats after 8 days (acute) and 29 days (chronic) administration of 1 mg/kg of subcutaneous Ang(1–7) in 4 dosing conditions: 0×, 1×, 3×, or 7×/week. The graphs describe results for (A) Ang(1–7); (B) AngII; (C) Ang(1–7)/Ang (II) ratio; (D) ACE2; (E) ACE; and (F) ACE2/ACE ratio. Data are presented as mean ± SD. Asterisks denote p < 0.05 from the 0×/week condition at respective time point
