Table 1.

Summary of correlation, mean bias, slope and 95% confidence intervals (CI) for [¹⁸F]FDG and [¹⁸F]AlF-NOTA-OC using different preclinical dosimetry models versus clinical measurements.

Dosimetry model	r2	Mean % bias	Slope, mean ± SEM	95% CI slope
	[18F]FDG
Adult male, non-normalised, FBP	0.754	111.1	2.111 ± 0.1083	1.898, 2.323
Adult male, normalised, FBP	0.855	40.44	0.5956 ± 0.02207	0.5523, 0.6388
Adult male, non-normalised, iterative	0.786	274.2	3.742 ± 0.1752	3.398, 4.085
Adult male, normalised, iterative	0.865	11.26	1.126 ± 0.03988	1.047, 1.204
Adult female, non-normalised, FBP	0.751	194.1	2.941 ± 0.1486	2.650, 3.233
Adult female, normalised, FBP	0.846	22.07	0.7793 ± 0.02916	0.7222, 0.8365
Adult female, non-normalised, iterative	0.785	425.1	5.251 ± 0.2412	4.779, 5.724
Adult female, normalised, iterative	0.886	47.87	1.487 ± 0.04684	1.395, 1.579
	[18F]AlF-NOTA-OC
Adult male, non-normalised, FBP	0.4224	39.7	1.397 ± 0.2584	0.8753, 1.920
Adult male, normalised, FBP	0.5055	58.34	0.4166 ± 0.06515	0.2849, 0.5483
Adult male, non-normalised, iterative	0.436	156	2.560 ± 0.4603	1.629, 3.490
Adult male, normalised, iterative	0.5098	22.01	0.7799 ± 0.1209	0.5356, 1.024
Adult female, non-normalised, FBP	0.3996	89.7	1.897 ± 0.3588	1.173, 2.622
Adult female, normalised, FBP	0.4917	45.96	0.5404 ± 0.08479	0.3693, 0.7116
Adult female, non-normalised, iterative	0.4119	246.7	3.467 ± 0.6393	2.177, 4.758
Adult female, normalised, iterative	0.503	1.9	1.019 ± 0.1564	0.7037, 1.335