Table 3.
Performance on key measures of seven cognitive tasks by male and female deletion carriers and controls
| Cognitive task | Control group | Deletion group | Statistical comparison | Benjamini-Hochberg corrected p value |
| Male participants | ||||
| Pairs Matching Test (total number of errors) | −0.11 (−0.11 to −0.11) (n=42 990) | 0.25 (−0.11 to 0.54) (n=86) | B=0.202±0.112, β=0.009, p=0.071 | 0.166 |
| Reaction Time Test | −0.19 (−0.19 to −0.18) (n=42 626) | −0.025 (−0.19 to 0.265) (n=86) | B=0.217±0.101, β=0.010, p=0.032 | 0.112 |
| Fluid Intelligence Test (total number of correct answers) | 0.40 (−0.07 to 0.40) (n=13 072) | −0.07 (−0.55 to 0.40) (n=31) | B=−0.465±0.190, β=−0.021, p=0.014 | 0.098 |
| Digit Span Test (maximum number of digits remembered) | 0.21 (0.21 to 0.21) (n=4195) | 0.21 (−0.165 to 0.97) (n=10) | U=18 543.5, p=0.512 | 0.563 |
| Symbol Digit Substitution Test (number of correct substitutions) | 0.05 (0.05 to 0.05) (n=11 664) | −0.35 (−0.838 to 0.345) (n=13) | U=63 851, p=0.323 | 0.452 |
| Trail Making Test A (time to completion) | −0.19 (−0.22 to −0.17) (n=10 580) | −0.04 (−0.43 to 1.07) (n=14) | U=58 547, p=0.175 | 0.306 |
| Trail Making Test B (time to completion) | −0.11 (−0.13 to −0.10) (n=10 588) | 0.125 (−0.53 to 0.44) (n=14) | U=67 499, p=0.563 | 0.563 |
| Female participants | ||||
| Pairs Matching Test (total number of errors) | −0.11 (−0.11 to −0.11) (n=54 151) | 0.25 (−0.11 to 0.25) (n=312) | B=0.105±0.057, β=0.008, p=0.067 | 0.235 |
| Reaction Time Test | 0.01 (0.01 to 0.01) (n=53 692) | −0.10 (−0.24 to 0.0495) (n=309) | B=−0.0202±0.052, β=−0.002, p=0.697 | 0.835 |
| Fluid Intelligence Test (total number of correct answers) | −0.07 (−0.07 to −0.07) (n=16 615) (mean: 0.05±0.0074) |
−0.07 (−0.55 to −0.07) (n=103) (mean: −0.31±0.0972) |
B=−0.352±0.096, β=−0.028, p<0.001 | <0.0063 |
| Digit Span Test (maximum number of digits remembered) | 0.21 (0.21 to 0.21) (n=5386) | 0.21 (−0.54 to 0.59) (n=36) | B=0.058±0.160, β=0.005, p=0.716 | 0.835 |
| Symbol Digit Substitution Test (number of correct substitutions) | 0.05 (0.05 to 0.05) (n=15 163) | 0.15 (−0.25 to 0.54) (n=64) | B=−0.063±0.114, β=−0.004, p=0.581 | 0.835 |
| Trail Making Test A (time to completion) | −0.02 (−0.04 to 0.00) (n=13 179) | 0.015 (−0.28 to 0.29) (n=58) | B=0.020±0.126, β=0.001, p=0.875 | 0.875 |
| Trail Making Test B (time to completion) | 0.01 (−0.01 to 0.03) (n=13 206) | 0.08 (−0.17 to 0.385) (n=58) | B=0.123±0.121, β=0.009, p=0.307 | 0.716 |
Data are presented as median z-scores with 95% confidence limits.