TABLE 2.
Blood and urine data at day 22
| Parameter | Control | TOL | CP | CP + TOL |
|---|---|---|---|---|
| Urea (mg/dL) | 39.500 ± 1.0690a | 41.250 ± 4.4320a | 67.625 ± 1.8468b | 49.750 ± 1.1650c |
| Creatinine (mg/dL) | 0.4125 ± 0.27999a | 0.2625 ± 0.10607a | 2 ± 0.16903b | 0.7125 ± 0.08345c |
| Serum Na+ (mmol/L) | 147.250 ± 5.2576a | 149.875 ± 2.6959a | 118.625 ± 1.3025b | 134.000 ± 1.7728c |
| Serum K+ (mmol/L) | 4.038 ± 0.2264a | 4.375 ± 0.6112a | 5.713 ± 0.0991b | 4.238 ± 0.2134a |
| Serum osmolarity (mosmole/kg H2O) | 301.0913 ± 10.39010a | 305.9050 ± 5.29577a | 245.1225 ± 2.72161b | 274.5975 ± 2.84485c |
| Urine volume (mL) | 9.75 ± 0.267a | 11.88 ± 0.354b | 5.94 ± 0.320c | 8.25 ± 0. 267d |
| Urinary creatinine (mg/dL) | 71.250 ± 4.0620a | 70.000 ± 6.5465a | 49.875 ± 1.2464b | 63.750 ± 2.2520c |
| Urinary Na+ (mEq/L) | 92.025 ± 1.4109a | 91.750 ± 1.8323a | 93.375 ± 1.7678a | 92.875 ± 1.8077a |
| FeNa | 0.3587 ± 0.23955a | 0.2338 ± 0.10378a | 3.1563 ± 024242b | 0.7763 ± 0.09870c |
| CH2O | −0.004225 ± 0.0008345a | −0.005700 ± 0.0006047b | −0.010362 ± 0.0006435c | −0.007813 ± 0.0002850d |
| Urine osmolarity (mosmole/kg H2O) | 565.000 ± 43.6447a | 516.250 ± 20.6588b | 861.250 ± 33.9905c | 650.000 ± 15.1186d |
Different superscripts (a‐c) in the same row indicate significant difference (P < .05) among groups.
TOL group was performed to show the effect of TOL on water and electrolyte balance with normal kidney in comparison to the control group: as shown TOL performed its effect by regulating the free water excretion that resulted in decreasing the urine osmolarity.