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. 2020 Aug 1;31(17):1879–1891. doi: 10.1091/mbc.E20-04-0233

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© 2020 Baumhardt et al. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.

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FIGURE 1: — Glu571 of CRM1 is located near the β-strand of bound NESs. (A) Structure of CRM1 (gray) bound to RanGTP (light blue) and the NES of Mek1 (cyan). (B) Left panel: details of the Mek1^NES-bound CRM1 groove, showing the Glu571 side chain of CRM1 (gray) and the side chains of the NES β-strand (cyan). Middle panel: surface representation of the NES-binding groove, with the NES peptide removed and rotated along the vertical axis to show the hydrophobic φ0-4 side chains (right panel). (C, D) Details of the Smad4^NES-bound (C; brown; 5UWU) and hRio2^NES-bound (D; purple; 5DHF) CRM1 grooves, showing the Glu571 side chains of CRM1 and the side chains of the NES β-strands.