Fig. 2.

Preclinical ARB effects on cerebrovascular, cognitive, and pathological deficits in AD mouse models. Schematic representation of preclinical ARB interventions, including telmisartan, losartan, olmesartan, valsartan, and candesartan, and their respective effects on cerebrovascular, cognitive, and pathological deficits on a variety of AD mouse models. CBF, cerebral blood flow; EC, endothelial cell; SMC, smooth muscle cell; NO, nitric oxide; LTP, long-term potentiation; ROS, reactive oxygen species; PPAR-γ, peroxisome proliferator-activated receptor gamma; Aβ, amyloid-β; TNFα, tumor necrosis factor-α; SOD2, superoxide dismutase 2