Fig. 7.

AT2R activation decreased dense core Aβ plaque load, while AT4R agonism had no effect on Aβ plaque load. Cortical and hippocampal dense core Aβ plaque load measured by thioflavin S was significantly reduced following AT2R agonism with compound 21 (C21) (a) (from Royea et al. 2020a). AngIV treatment had no effect on cortical or hippocampal dense core Aβ plaque load measured by thioflavin S (from Royea et al. 2020b). *p < 0.05; **p < 0.01. Reproduced with permission