Fig. 3.

Overview of PPAR signaling and mechanism for PPARα-mediated autophagy activation in innate immune system. Initially, lipid molecule enters the cell and is quickly bound by a fatty acid binding protein. The fatty acid binding protein transports the lipid to a PPAR which in turn activates a corresponding RXR. The PPAR-RXR complex crosses into the nucleus and facilitate expression of required genes. In the case of tuberculosis infection, PPARα upregulates the expression of TFEB which, in turn, drives the expression of autophagy related genes, LAMP3 and RAB7 thus stimulating autophagy