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. 2020 Sep 29;20:473. doi: 10.1186/s12935-020-01549-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — ADAM17 was a target of miR-324-3p. a The complementary sequences between miR-324-3p and ADAM17. b, c The fluorescence intensities of ADAM17-WT and ADAM17-MUT in HCT116/OxR and HCT8/OxR cells transfected with miR-324-3p. d, e Measurement of ADAM17 mRNA and protein expression in Ox-resistant CRC tissues (n = 40) and Ox-sensitive CRC tissues (n = 40). f The relationship between miR-324-3p and ADAM17 in Ox-resistant CRC tissues (n = 40). g, h Detection of ADAM17 mRNA and protein expression in Ox-resistant CRC cells, CRC cells, and FHC cells. i, j The protein expression of ADAM17 in HCT116/OxR and HCT8/OxR cells transfected with sh-NC, sh-MALAT1, sh-MALAT1 + miR-NC, or sh-MALAT1 + miR-324-3p. N = 3, *P < 0.05