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. 2020 Sep 29;20:473. doi: 10.1186/s12935-020-01549-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — ADAM17 up regulation could abrogate the effect of MALAT1 reduction on the sensitivity of Ox-resistant CRC cells. a, b The transfection efficiency of ADAM17 in Ox-resistant CRC cells. c–k HCT116/OxR and HCT8/OxR cells were transfected with sh-NC, sh-MALAT1, sh-MALAT1 + pcDNA, or sh-MALAT1 + ADAM17. c, d The detection of IC50 value of Ox in HCT116/OxR and HCT8/OxR cells. e, f Measurement of cell viability by CCK-8 assay. g, h Measurement of cell migration HCT116/OxR and HCT8/OxR cells by transwell assay. i Determination of cell apoptosis in HCT116/OxR and HCT8/OxR cells by flow cytometry. j, k The expression of Bcl-2, Cleaved caspase-3, E-cadherin and Vimentin was detected by western blot. N = 3, *P < 0.05