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. 2020 Sep 25;15:7079–7096. doi: 10.2147/IJN.S250001

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© 2020 Badrigilan et al.

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(A) Pharmacokinetics (PK) include absorption, distribution, metabolism, and excretion (ADME) of a molecule or nanoprobe. RES: reticuloendothelial system, EPR: enhanced permeability and retention; (B) The one-compartment and two-compartment PK models for plotting blood concentration-time curves of a molecule or nanoprobe. Reprinted with permission from Yu M, Zheng J. Clearance pathways and tumor targeting of imaging nanoparticles. ACS Nano. 2015;9(7):6655–6674.⁷⁶ Copyright 2015, American Chemical Society.