Skip to main content
. 2020 Sep 25;15:7079–7096. doi: 10.2147/IJN.S250001

Table 1.

The Maximum Safe Doses of Bismuth-Based Nanomaterials After 24h of Incubation

Nanomaterials Cell Lines Dose
(µg• mL−1)
References Nanomaterials Cell Lines Dose
(µg• mL−1)
References
Cu3BiS3 4T1 200 29 Bi HeLa 500 18
HeLa
MCF-7
200 44 U937
HepG2
10,000 37
HUVEC*
BEL-7402
100 45 MCF-7
SMMC-7721
VSMC
400 46
HeLa
L929*
200 31 4T1
HUVEC*
200 47
HeLa 600 5 U14 500 1
MCF-7 150 48 4T1
L02*
400 32
HeLa 200 49 4T1
NIH-3T3
HUVEC
160 50
Bi2Se3 4T1
3T3*
200 26 HeLa
MCF-7
500 34
MCF-7 200 51 HeLa 600 23
HeLa
HUVEC*
400 3 HeLa
HUVEC*
300 4
H22 200 52 4T1 100 53
BEL-7402 100 7 HeLa 400 30
HeLa 200 8 Bi2S3 4T1 300 24
HeLa 200 54 4T1 160 28
BiFe BJ5ta*
HepG2
100 27 HeLa
HUVEC*
300 2
HeLa
MCF-7
500 34 4T1
J774
15,000 55
HepG2 3000 10 HeLa 7500 41
Bi2S3/Au 4T1
MCF-7
100 56 Bi2S3/G HUVEC*
HeLa
MCF-7
HepG2
BEL-7402
40 6
FeSe2/Bi2S3 4T1 200 9 PC3 200 25
BiSe/G HeLa 150 33 BiOCl MCF-7 200 57
GdBi C6
COS-7*
200 58 L929 500 59
Bi2WO6 HeLa 800 11 Bi2O3:Yb3+/Er3+ HeLa 1000 60
HUVE
HeLa
400 61 Bi2S3/FeS2 4T1 800 62
GBi HeLa
MCF-7
500 35 BiOI HeLa 4200 63
BMS HUVE
HeLa
200 64 4T1
HeLa
200 65
K0.3Bi0.7F2.4 HeLa 500 66 (BiO)2CO3 Huh-7 5mM 48
BiOBr L929 1000 67 Bi2S3-MnO2 U14 10 68
AgBiS2 UMR-106 500 69 BPZP 4T1 100 70

Note: * The cells are non-cancer cells.

Abbreviations: 3T3, mouse embryonic fibroblast; 4T1, breast cancer cell; AgBiS2 NPs, silver bismuth sulfide; BEL-7402, liver carcinoma cell; BJ5ta, human fore skin fibroblast; Bi, pure bismuth; Bi2S3, bismuth sulfide; Bi2Se3, bismuth selenide; Bi2S3/Au, bismuth sulfide-gold; Bi2S3/G, bismuth sulfide-graphene; Bi2S3-MnO2 NPs, bismuth sulfide and manganese oxide nanocomposites; Bi2WO6, bismuth tungstate; BiFe, bismuth ferrite; (BiO)2CO3, bismuth subcarbonate; BiOBr, bismuth oxybromide; BiOCl, bismuth oxychloride; BiOI, bismuth oxyiodide; BMS NRs, bismuth sulfide -mesoporous silica; BPZP, bismuth sulfide-linked zinc protoporphyrin; BiSe/G, bismuth selenide-graphene; C6, glioma cell; COS-7, monkey kidney fibroblasts; Cu3BiS3, copper bismuth sulfide; FeSe2/Bi2S3, iron diselenide-bismuth selenide; GBi, graphene-bismuth; GdBi, gadolinium-bismuth; H22, hepatic carcinoma cell; HeLa, cervical cancer cell; HepG2, hepatic carcinoma cell; Huh-7, human liver cell; HUVEC, human umbilical vein endothelial cell; J774, Mus muscles reticulum cell sarcoma; L02, human hepatic cell; L929, murine fibroblast cell; MCF-7, breast cancer cell; PC3, human prostate carcinoma; SMMC-7721, hepatic carcinoma cell; U14, cervical carcinoma cell; U937, macrophage cells; VSMC, vascular smooth muscle cell.