Table 5.

Multivariable analysis for survival outcome (N = 5,697)

	Disease-free survival			Cause-specific survival
Characteristic	5-yr (%)	HR (95%CI)	P-value	5-yr (%)	HR (95%CI)	p-value
Age (years)			0.23			0.20
<40	83.4%	1		88.8%	1
40–49	81.9%	0.98 (0.81–1.17)	0.81	89.6%	0.84 (0.67–1.05)	0.13
≥50	78.5%	1.11 (0.94–1.30)	0.22	88.1%	0.85 (0.69–1.03)	0.10
Histology			<0.001			<0.001
SCC	83.2%	1		90.2%	1
Adeno	76.6%	1.73 (1.49–2.00)	<0.001	87.5%	1.62 (1.33–1.97)	<0.001
AS	77.8%	1.56 (1.25–1.96)	<0.001	83.5%	1.91 (1.47–2.47)	<0.001
Others	63.1%	2.13 (1.31–3.46)	0.002	70.9%	2.04 (1.14–3.65)	0.016
Tumor size
≤4 cm	84.5%	1		92.0%	1
>4 cm	71.4%	1.27 (1.10–1.46)	0.001	81.0%	1.43 (1.20–1.71)	<0.001
Parametrea
Not involved	85.9%	1		92.8%	1
Involved	59.4%	1.80 (1.55–2.11)	<0.001	72.0%	1.71 (1.41–2.07)	<0.001
Deep stromal invasion
Not involved	89.8%	1		96.2%	1
Involved	72.9%	1.34 (1.12–1.60)	0.001	82.5%	1.80 (1.39–2.33)	<0.001
LVSI
No	90.2%	1		96.1%	1
Yes	73.1%	1.56 (1.31–1.86)	<0.001	83.0%	1.97 (1.52–2.55)	<0.001
Uterine corpus
Not involved	83.5%	1		91.1%	1
Involved	64.1%	1.10 (0.93–1.30)	0.28	74.0%	1.33 (1.09–1.62)	0.005
Pelvic lymph node
Not involved	87.5%	1		94.1%	1
Involved	61.1%	2.16 (1.86–2.50)	<0.001	73.4%	2.31 (1.91–2.79)	<0.001
Para–aortic lymph node			0.09			0.11
Not involved	81.3%	1		87.7%	1
Involved	35.1%	1.47 (1.04–2.06)	0.028	50.1%	1.47 (0.99–2.17)	0.05
Clinically not involved	81.7%	1.11 (0.93–1.33)	0.26	89.8%	1.03 (0.82–1.29)	0.82
Peritoneal cytology
No	83.5%	1		90.8%	1
Yes	72.2%	1.10 (0.95–1.27)	0.22	81.9%	1.05 (0.88–1.27)	0.59
Ovarian metastasis
No	81.5%	1		89.3%	1
Yes	22.9%	2.19 (1.56–3.09)	<0.001	41.5%	2.32 (1.61–3.36)	<0.001

Cox proportional hazard regression model for multivariable analysis. All the listed covariates were entered in the final model. Significant p-values (cutoff, p < 0.05) are emboldened.

Abbreviations: HR: hazard ratio; CI: confidence interval; SCC: squamous cell carcinoma; Adeno: adenocarcinoma; AS: adenosquamous; LVSI: lympho-vascular space invasion.