TABLE III.

Independent Risk Factor for Pelvic and/or Para-Aortic Lymph Node Metastasis

			Depth of LVSI		Extent of LVSI		Depth/extent of LVSI
	No.	Mets (%)	OR (95%CI)	P-value	OR (95%CI)	P-value	OR (95%CI)	P-value
Age				0.16		0.28		0.21
<60	212	11.3%	1		1		1
≥60	88	11.4%	0.42 (0.13–1.41)		0.52 (0.16–1.71)		0.45 (0.13–1.56)
Race				0.19		0.12		0.15
Non-hispanic	120	9.2%	1		1		1
Hispanic	180	12.8%	2.09 (0.69–6.34)		2.58 (0.79–8.39)		2.41 (0.74–7.91)
BMI (kg/m2)				0.03		0.017		0.032
<30	110	18.2%	1		1		1
≥30	188	7.4%	0.30 (0.10–0.89)		0.26 (0.09–0.79)		0.30 (0.10–0.90)
Histology				0.98		0.73		0.8
Endometrioid	248	10.5%	1		1		1
Non-endometrioid	52	15.4%	0.98 (0.24–3.93)		0.77 (0.18–3.37)		0.83 (0.19–3.64)
Grade				0.11		0.27		0.13
1–2	216	7.9%	1		1		1
3	84	20.2%	0.31 (0.07–1.32)		0.46 (0.12–1.81)		0.32 (0.07–1.42)
Myometrial invasion (%)				0.001		0.002		0.002
≤50%	207	2.9%	1		1		1
>50%	92	30.4%	7.03 (2.21–22.4)		6.26 (1.92–20.4)		6.33 (1.93–20.8)
Cervical stromal invasion				0.019		0.017		0.017
No	257	7.0%	1		1		1
Yes	43	37.2%	3.80 (1.24–11.6)		3.95 (1.28–12.1)		3.97 (1.28–12.3)
Adnexal involvement				0.012		0.015		0.012
No	271	8.5%	1		1		1
Yes	29	37.9%	5.92 (1.48–23.7)		5.48 (1.39–21.6)		6.00 (1.49–24.1)
Depth of LVSI
None	245	4.1%	1
Superficial	22	22.7%	6.48 (1.52–27.6)	0.011
Deep	33	57.6%	33.8 (7.36–155)	<0.001
Extent of LVSI
None	245	4.1%			1
Focal	44	36.4%			11.4 (3.32–38.9)	<0.001
Extensive	11	72.7%			49.9 (5.81–428)	<0.001
Combination LVSI
None	245	4.1%					1
Superficial/focal	22	22.7%					6.43 (1.51–27.4)	<0.001
Deep/focal	22	50.0%					26.3 (5.17–134)	<0.001
Deep/extensive	11	72.7%					63.9 (7.14–571)	<0.001

Multivariate analysis with binary logistic regression test for P-values. Three hundered cases of pelvic and/or para-aortic lymphadenectomy were examined. Three different patterns of LVSI are tested in the analysis. Covariates listed in table are entered in the final model. Significant P-values are in bold.

BMI, body mass index; and LVSI, lymphovascular space invasion.