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. Author manuscript; available in PMC: 2020 Sep 30.
Published in final edited form as: Clin Appl Thromb Hemost. 2016 Aug 31;23(8):1018–1027. doi: 10.1177/1076029616665925

Figure 2.

Figure 2.

Schema of paraneoplastic thrombocytosis disruption and venous thromboembolism. In this feed-forward loop theory, IL-6 derived from the tumor stimulates the hepatocyte to produce TPO. Thrombopoietin stimulates bone marrow to produce platelets. Interleukin 6 and thrombocytosis reflect the development of VTE. Disruption of the loop by NAFLD can therefore decrease the VTE risk. IL-6 indicates interleukin 6; NAFLD, nonalcoholic fatty liver disease; TPO, thrombopoietin; VTE, venous thromboembolism.