Table 2.
Sensitivity and specificity using each cut-off score (N = 68)
| Criterion | Sensitivity | 95% CI | Specificity | 95% CI | +PV | 95% CI | -PV | 95% CI | Costa |
|---|---|---|---|---|---|---|---|---|---|
| ≥1 | 100.00 | 79.4–100.0 | 0.00 | 0.0–6.8 | 23.5 | 23.5–23.5 | 0.765 | ||
| > 1 | 100.00 | 79.4–100.0 | 7.69 | 2.1–18.5 | 25.0 | 23.6–26.5 | 100.0 | 0.706 | |
| > 2 | 100.00 | 79.4–100.0 | 15.38 | 6.9–28.1 | 26.7 | 24.5–29.0 | 100.0 | 0.647 | |
| > 3 | 100.00 | 79.4–100.0 | 21.15 | 11.1–34.7 | 28.1 | 25.3–31.0 | 100.0 | 0.603 | |
| > 4 | 93.75 | 69.8–99.8 | 40.38 | 27.0–54.9 | 32.6 | 27.2–38.5 | 95.5 | 75.4–99.3 | 0.471 |
| > 5 | 93.75 | 69.8–99.8 | 50.00 | 35.8–64.2 | 36.6 | 29.9–43.8 | 96.3 | 79.3–99.4 | 0.397 |
| > 6 | 75.00 | 47.6–92.7 | 63.46 | 49.0–76.4 | 38.7 | 28.6–49.9 | 89.2 | 77.5–95.2 | 0.338 |
| > 7 | 75.00 | 47.6–92.7 | 73.08 | 59.0–84.4 | 46.2 | 33.5–59.3 | 90.5 | 80.0–95.8 | 0.265 |
| > 8 | 62.50 | 35.4–84.8 | 82.69 | 69.7–91.8 | 52.6 | 35.4–69.2 | 87.8 | 79.0–93.2 | 0.221 |
| >9b,c | 56.25 | 29.9–80.2 | 92.31 | 81.5–97.9 | 69.2 | 44.4–86.4 | 87.3 | 79.6–92.3 | 0.162 |
| > 10 | 37.50 | 15.2–64.6 | 96.15 | 86.8–99.5 | 75.0 | 40.1–93.1 | 83.3 | 77.3–88.0 | 0.176 |
| > 11 | 31.25 | 11.0–58.7 | 98.08 | 89.7–100.0 | 83.3 | 38.6–97.5 | 82.3 | 76.9–86.6 | 0.176 |
| > 12 | 12.50 | 1.6–38.3 | 100.00 | 93.2–100.0 | 100.0 | 78.8 | 75.5–81.7 | 0.206 | |
| > 13 | 6.25 | 0.2–30.2 | 100.00 | 93.2–100.0 | 100.0 | 77.6 | 75.3–79.7 | 0.221 | |
| > 14 | 0.00 | 0.0–20.6 | 100.00 | 93.2–100.0 | 76.5 | 76.5–76.5 | 0.235 |
+PV positive predictive value, −PV negative predictive value, CI confidence interval, aTaking into account disease prevalence (23.5%) and estimated costs, bYouden index J, cOptimal criterion