Table 1.

Serum soluble EGFR and adipsin levels and metabolic characteristics of T2DM patients and NGT subjects

	NGT		T2DM		P value
	n	Value	n	Value
Serum soluble EGFR (ng/mL)	47	62.3 ± 1.2	106	64.7 ± 0.9	0.11
Serum adipsin (μg/mL)	47	5.9 ± 0.3	106	5.8 [4.7–7.1]	0.55
Age (years)	47	54 [44–65]	106	56 [49–65]	0.06
Sex (No. men/women)	13/34	–	66/40	–	< 0.01
BMI	47	22.9 [20.6–29.4]	106	27.1 [23.9–30.9]	0.21
Waist circumference (cm)	25	90.0 [82.8–105.0]	71	96.0 [88.0–105.0]	0.33
Systolic blood pressure (mmHg)	42	126.5 [114.5–145.3]	102	134.4 ± 1.9	0.26
Diastolic blood pressure (mmHg)	42	82.2 ± 2.2	102	84.2 ± 1.3	0.4
Fasting blood glucose (mg/dL)	46	100.2 ± 1.3	106	161.0 [134.8–184.0]	< 0.01
Fasting serum insulin (μIU/mL)	41	8.2 [4.9–10]	83	9.6 [6.0–15.5]	0.16
C-peptide (ng/mL)	29	2.2 [1.4–3.2]	100	2.4 [1.6–3.2]	0.84
HOMA-IR	41	2.2 [1.1–2.7]	83	4.0 [2.4–6.4]	< 0.01
CPR-index	29	2.1 [1.5–2.9]	100	1.4 [0.9–2.1]	< 0.01
HbA1c (%)	45	5.7 ± 0.1	106	9.3 [7.9–10.2]	< 0.01
HbA1c (mmol/mol)	45	39 ± 0.5	106	78 [63–88]	< 0.01
Total cholesterol (mg/dL)	41	200 ± 5.9	102	187.0 [165.8–211.0]	0.24
LDL-cholesterol (mg/dL)	45	122.6 ± 4.6	105	110.0 [89.5–126.5]	0.03
HDL-cholesterol (mg/dL)	45	61.2 ± 2.6	106	42.0 [37.0–54.0]	< 0.01
Triglycerides (mg/dL)	45	100.0 [78.0–128.5]	106	141.5 [96–213.5]	< 0.01
AST (IU/L)	45	20.0 [15.5–22.5]	106	24.0 [18.0–38.0]	< 0.01
ALT (IU/L)	45	17.0 [11.0–25.5]	106	28.5 [19.0–50.0]	< 0.01
γGTP (IU/L)	44	21.5 [14.3–31.3]	105	37.0 [23.0–67.5]	0.04
FIB4-index	27	1.0 ± 0.1	95	1.6 ± 0.2	< 0.01
eGFR (mL/min/1.73 m2)	47	81.3 ± 2.5	106	83.2 ± 2.0	0.58

BMI, Body mass index; EGFR, Epidermal growth factor receptor; eGFR, Estimated glomerular filtration rate; NGT, Normal glucose tolerance; T2DM, Type 2 diabetes