Table 3.
Hazard of Incident Fracture per Standard Deviation Decrement in Premenopausal or Early Postmenopausal Trabecular Bone Score (TBS), Lumbar Spine (LS) BMD, and Femoral Neck (FN) BMD, Before and After Mutual Adjustment, Study of Women’s Heath Across the Nation TBS Study a, b
| Menopause Transition Stage | Predictor | Model with TBS Only c | Model with LS BMD Only c | Model with FN BMD Only c | Model with TBS and LS BMD c | Model with TBS and FN BMD c | Model with TBS, LS BMD and Prior Fracture c | Model with TBS, FN BMD and Prior Fracture c |
|---|---|---|---|---|---|---|---|---|
| Premenopausal | TBS | 1.17 (1.02, 1.35) | - | - | 0.95 (0.79, 1.14) | 1.02 (0.87, 1.19) | 0.94 (0.79, 1.12) | 1.00 (0.86, 1.17) |
| LS BMD | - | 1.36 (1.19, 1.57) | - | 1.41 (1.18, 1.67) | - | 1.39 (1.16, 1.65) | - | |
| FN BMD | - | - | 1.50 (1.27, 1.78) | - | 1.49 (1.24, 1.79) | - | 1.48 (1.23, 1.78) | |
| Early Postmenopausal | TBS | 1.15 (0.95, 1.39) | - | - | 1.03 (0.79, 1.33) | 0.96 (0.77, 1.21) | 0.99 (0.76, 1.30) | 0.94 (0.74, 1.18) |
| LS BMD | - | 1.25 (0.99, 1.57) | - | 1.22 (0.89, 1.66) | - | 1.21 (0.88, 1.65) | - | |
| FN BMD | - | - | 1.58 (1.20, 2.08) | - | 1.63 (1.18, 2.24) | - | 1.55 (1.13, 2.12) |
Premenopausal analysis sample includes women who were premenopausal, defined as no change in predictability of menses, or early perimenopausal, defined as decreased cycle predictability, but no menstrual gaps of ≥3 months at the time of their first TBS measurement.
The early postmenopausal sample is a subset of the premenopausal sample. It consists of women who had TBS assessed at their first study visit after becoming postmenopausal and attended at least one subsequent visit.
All models were adjusted for age, menopause transition stage (premenopausal sample only [pre or early perimenopausal]), race/ethnicity, SWAN-TBS clinical site, BMI linear spline (< 24, 24 to 31, >31), and percent of visits at which use of calcium, vitamin D, bone beneficial or bone adverse medications were reported (see methods for list of bone medications). Age, MT stage (premenopausal sample only), weight, height and BMI values were those measured at the visit corresponding to the primary TBS (and/or BMD) predictor.