Table 3.

Multivariable-adjusted hazard ratios of incident CHD according to the 1-SD increase in TyG-index, stratified by genders: Tehran Lipid and Glucose Study

Variables	Male (n = 4154)		Female (n = 3366)		Total (n = 7520)
	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value
TyG-index	1.16 (1.05–1.29)	0.005	1.23 (1.07–1.39)	0.003	1.19 (1.10–1.29)	< 0.001
Age (years)	1.05 (1.04–1.06)	< 0.001	1.04 (1.03–1.05)	< 0.001	1.05 (1.04–1.05)	< 0.001
WC (cm)	1.02 (1.00–1.04)	0.036	1.02 (1.00–1.03)	0.066	1.02 (1.01–1.03)	0.004
BMI (kg/m2)	0.96 (0.92–1.01)	0.100	0.97 (0.94–1.01)	0.162	0.97 (0.94–1.00)	0.020
Education (years)
< 6	Reference		Reference		Reference
6–12	1.21 (0.98-1.49)	0.075	0.81 (0.60–1.09)	0.161	1.04 (0.88–1.23)	0.629
≥ 12	1.02 (0.76-1.36)	0.904	0.57 (0.27–1.17)	0.122	0.88 (0.68–1.15)	0.343
Smoking
Never	Reference		Reference		Reference
Past	1.39 (1.11–1.75)	0.004	1.08 (0.65–1.80)	0.768	1.34 (1.09–1.64)	0.005
Current	1.67 (1.37–2.04)	< 0.001	1.68 (1.08–2.59)	0.020	1.68 (1.41–2.01)	< 0.001
Low physical activity	1.09 (0.90–1.32)	0.382	1.06 (0.84–1.33)	0.650	1.08 (0.93–1.25)	0.325
FH-CVD	1.39 (1.10–1.74)	0.005	1.63 (1.30–2.06)	< 0.001	1.51 (1.28–1.77)	< 0.001
T2D	1.53 (1.20–1.95)	0.001	2.01 (1.54–2.61)	< 0.001	1.74 (1.46–2.08)	< 0.001
Hypertension	1.45 (1.19–1.76)	< 0.001	1.73 (1.37–2.17)	< 0.001	1.57 (1.35–1.81)	< 0.001
Lipid drug	0.91 (0.56–1.48)	0.696	1.24 (0.91–1.69)	0.171	1.12 (0.87–1.45)	0.380
LDL-C (mmol/L)	1.37 (1.25–1.50)	< 0.001	1.21 (1.09–1.33)	< 0.001	1.30 (1.22–1.39)	< 0.001
HDL-C (mmol/L)	0.71 (0.48–1.06)	0.097	0.69 (0.46–1.03)	0.072	0.72 (0.54–0.96)	0.023
Gender (female)	–	–	–	–	0.60 (0.50–0.71)	< 0.001

CHD coronary heart disease, SD standard deviation, TyG-index triglyceride glucose-index, HR hazard ratio, CI confidence interval, WC waist circumference, BMI body mass index, FH-CVD family history of cardiovascular disease, T2D type 2 diabetes, LDL-C low density lipoprotein cholesterol, HDL-C high density lipoprotein cholesterol