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. 2020 Sep 29;12:121. doi: 10.1186/s13195-020-00689-0

Table 3.

Recalculated cutoffs for freshly measured CSF core AD biomarkers with their 95% CI. Cutoff fresh R: cutoff transferred by applying Passing Bablok regression. Cutoff fresh Y: cutoff calculated maximizing the Youden’s index for fresh samples, by taking as reference the classification performed on frozen ones

Biomarker Cutoff frozen Cutoff fresh R (95%CI) Cutoff fresh Y (95%CI)
Aβ42/Aβ40 0.069 0.067 (0.060, 0.075) 0.062 (0.061, 0.075)
p-tau 56.5 57.2 (55.7, 59.7) 55.1 (52.3, 60.9)
t-tau 404 419 (379, 473) 419 (406, 581)